Enalapril Maleate
Enalapril for animals is an ACE (Angiotensin Converting Enzyme) inhibitor. inhibits the conversion of angiotensin I to angiotensin II.
Group
Enalapril Maleate is grouped into ACE Inhibitors and Vasodilators.
Mechanism of Action
Enalapril inhibits the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor and also stimulates sympathetic stimulation, renal hypertension, and the synthesis of aldosterone. The ability of aldosterone to cause sodium and water retention contributes to congestion.
Enalapril causes vasodilation and decreases aldosterone levels.
Dose Rates
Dog and Cats: 0.5 to 1 mg/kg body weight q12-24hrs PO
Indications
- To treat Hypertension
- To treat Congestive Heart Failure (CHF)
Pimobendan, Frusemide (with Spironolactone or alone), and Digoxin are used with Enalapril in the management of Congestive Heart Failure.
Contraindications
- Enalapril Maleate should not be given in Pregnant Animals
Interactions
- If used with multiple hypotension-causing drugs, it may cause severe hypotension.
Adverse effects
- Azotemia (In some patient)
Toxicity
An excessive dose of Enalapril can cause severe hypotension, which leads to the collapse of animals.
Management of hypotension in cases of toxicity should be done accordingly–
- Fluid therapy
- Adrenaline
- Naloxone– an opioid receptor antagonist, has been shown to increase blood pressure in ACE inhibitor overdoses (read here)
- Activated Charcoal in case of oral ingestion
Preparations
Only oral preparations are used in animals.
Oral Preparations of Enalapril Maleate available-
- Tab. Envas 2.5 (Enalapril Maleate 2.5mg)
- Tab. Envas 5 (Enalapril Maleate 5mg)
- Tab. Envas 10 (Enalapril Maleate 10mg)
- Tab. Dilvas-2.5 (Enalapril Maleate 5mg)
- Tab. Dilvas-5 (Enalapril Maleate 5mg)
- Tab. Dilvas-10 (Enalapril Maleate 10mg)
- Tab. Enatol-5 (Enalapril Maleate 5mg)
- Tab. Enatol-10 (Enalapril Maleate 10mg)
- Tab. Enapril-5 (Enalapril Maleate 5mg)
- Tab. Enapril-10 (Enalapril Maleate 10mg)
- Tab. Enace-2.5 (Enalapril Maleate 2.5mg)
- Tab. Enace-5 (Enalapril Maleate 5mg)
- Tab. Enace-10 (Enalapril Maleate 10mg)
- Tab. Lepril-2.5 (Enalapril Maleate 2.5mg)
- Tab. Lepril-5 (Enalapril Maleate 5mg)
- Tab. Lepril-10 (Enalapril Maleate 10mg)
More about Enalapril for animals
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